Purpose: The purpose of the grip strength test is to evaluate the strength of forelimb and
hind limb muscles. This test is useful in detecting changes in motor function and
muscle strength associated with drugs or other manipulations.
Description: In the grip strength test, the rodent is held by the nape of its neck and the base of its tail. Its forelimbs are placed on the tension bar and the rat is gently pulled back until it releases the bar. The distance the rodent pulls the bar before it releases its paw-grip is measured in kilograms of resistance by a strain gauge. Hindlimb strength can also be assessed.