Yao Liang Tang, MD, PhD, FAHA
Contact Info
Phone: (706) 721-8467
Fax: (706) 721-9799
Email: yaotang@augusta.edu
Office: CB-3303A
Lab: CB-3302, CB-3303
Education and Training
Postdoctoral Training
University of South Florida
Department of Pediatrics
2003-2004
Postdoctoral Training
University of Florida
Department of Physiology and Functional Genomics
2002-2003
PhD
Surgery
FuDan University
1997-2002
MD
Clinic Medicine
Shanghai Jiao Tong University
1988-1993
Society Memberships
Co-PI, NHLBI Progenitor Cell Biology Consortium (PCBC)
2011-present.
My primary research goals are to identify the molecular mechanisms of stem cell mediated cardiovascular protection and regeneration. More specifically, we are interested in (1) cross talking between HIF-1α and Notch signaling in homing, survival, and differentiation of stem cells; (2) exosomes-mediated survival signaling in stem cell mediated cardio protection; (3) the regulation of small non-coding RNA (microRNA) and long non-coding RNA (LncRNA) in stem cells; (4) cardiac differentiation of human induced pluripotent stem cells; (4) role of HDAC11 in cardiovascular disease. We found that hypoxic preconditioning enhances paracrine effects of CPC transplantation and improves heart function via angiogenesis and cardiovascular lineage differentiation. I have 10-year’s interdisciplinary research experience in mouse model of myocardial ischemia/reperfusion, mouse cardiovascular physiology, mouse vascular injury model, stem cell biology, molecular biology and histology.
Lan Zhang
Ma Q, Xia X, Tao Q, Lu K, Shen J, Xu Q, Hu X, Tang Y, Block NL, Webster KA, Schally AV, Wang J, Yu H. Profound Actions of an Agonist of Growth Hormone-Releasing Hormone on Angiogenic Therapy by Mesenchymal Stem Cells. Arterioscler Thromb Vasc Biol. 2016 36:00-00. DOI: 10.1161/ATVBAHA.116.307126.
Campbell CR, Berman AE, Weintraub NL, Tang YL. Electrical stimulation to optimize cardioprotective exosomes from cardiac stem cells. Med Hypotheses. 2016 Mar;88:6-9.
Zhao YT, Du J, Chen Y, Tang Y, Qin G, Lv G, Zhuang S, Zhao TC. Inhibition of Oct 3/4 mitigates the cardiac progenitor-derived myocardial repair in infarcted myocardium. Stem Cell Res Ther. 2015 Dec 24;6(1):259.
Teoh JP, Park KM, Broskova Z, Jimenez FR, Bayoumi AS, Archer K, Su H, Johnson J, Weintraub NL, Tang Y, Kim IM. Identification of gene signatures regulated by carvedilol in mouse heart. Physiol Genomics. 2015 Sep;47(9):376-85.
Archer K, Broskova Z, Bayoumi AS, Teoh JP, Davila A, Tang Y, Su H, Kim IM. Long Non-Coding RNAs as Master Regulators in Cardiovascular Diseases. Int J Mol Sci. 2015 Oct 5;16(10):23651-67.
Tang Y, Wang Y, Park KM, Hu Q, Teoh JP, Broskova Z, Ranganathan P, Jayakumar C, Li J, Su H, Tang Y, Ramesh G, Kim IM. MicroRNA-150 protects the mouse heart from ischaemic injury by regulating cell death. Cardiovasc Res. 2015;106(3):387-97.
Wang Y, Zhang L, Li Y, Chen L, Wang X, Guo W, Zhang X, Qin G, He SH, Zimmerman A, Liu Y, Kim IM, Weintraub NL, Tang Y. Exosomes/ microvesicles from induced pluripotent stem cells deliver cardioprotective miRNAs and prevent cardiomyocyte apoptosis in the ischemic myocardium. Int J Cardiol. 2015 192:61-9
Zhou J, Cheng M, Boriboun C, Ardehali MM, Jiang C, Liu Q, Han S, Goukassian DA, Tang YL, Zhao TC, Zhao M, Cai L, Richard S, Kishore R, Qin G. Inhibition of Sam68 triggers adipose tissue browning. J Endocrinol. 2015 Jun;225(3):181-9.
Cheng M, Huang K, Zhou J, Yan D, Tang YL, Zhao TC, Miller RJ, Kishore R, Losordo DW, Qin G, A critical role of Src family kinase in SDF-1/CXCR4-mediated bone-marrow progenitor cell recruitment to the ischemic heart. J Mol Cell Cardiol. 2015;81C:49-53
Tung W, Weintraub NL, Berman AE, Tang Y, A novel high throughput approach to screen for cardiac arrhythmic events following stem cell treatment. Med Hypotheses. 2015. pii: S0306-9877(15)00036-5. doi: 10.1016/j.mehy.2015.01.015