Brian Stansfield - Lab


Research   FACULTY PROFILE - Brian Stansfield

Faculty photo of Dr. David Fulton

The long term research interest in our laboratory is to understand the effect of inherited mutations in p21 Ras signaling on cardiovascular development and disease. Neurofibromatosis type 1 (NF1) is the result of inactivating mutations in the NF1 tumor suppressor gene and serves as a prototypical model of accelerated p21 Ras activity. NF1 patients are at increased risk of premature and severe cardiovascular disease, including hypertension, arterial stenosis, aneurysm formation, and Moya Moya. To interrogate these pathways, we utilize mutant and lineage-restricted transgenic mice in multiple model systems to induce cardiovascular disease. We are particularly interested in identifying patient-specific therapeutic targets and biomarkers of disease.

As a clinical neonatologist, I am also interested in understanding how prematurity and/or neonatal factors contribute to cardio-metabolic disease. We are active collaborators with investigators in the Georgia Prevention Institute and lead clinical projects focused on improving utilization and outcomes in patients undergoing extracorporeal membrane oxygenation (ECMO).

Projects

Department of Defense NF140031 "Characterizing Myeloid Cell Activation in NF1 Vasculopathy" 2015-2018.

Myeloid cells are principle cellular mediators of inward and outward cardiovascular remodeling in neurofibromin-deficient mice. The goal of this project is to understand how inflammation and oxidative stress, two innate properties of activated leukocytes, contribute to cardiovascular remodeling in neurofibromin-deficient mice.

Lab Personnel

Emily Pierce
Neonatal/Perinatal Medicine Fellow
2015 - current

Valerie Harris 
Research Associate

Farlyn Hudson 
Senior Research Associate

Itia (Tia) Lee 
Research Associate

Jordan Mattern
Resident

Hanna Rose 
Graduate Research Assistant

Rebekah Tritz 
Graduate Research Assistant

Hanfang Zhang
Postdoctoral Fellow