Proteomics and Metabolomics, a part of systems biology, is fundamental for a full understanding of a biological system. Mass spectrometry - based technologies have been indispensable to the development of molecular medicine. Clinical research can also benefit from proteomics and metabolomics by both the identification of new drug targets and the development of new diagnostic markers. The GCC Proteomics and Metabolomics Shared Resource uses mass spectrometry as the key technology for qualitative and quantitative protein characterization and advanced methods for profiling and quantitation of small molecules. Our principal approach for protein analysis is 'bottom-up' proteomics, where all proteins are proteolytically digested, producing peptide surrogates (signature peptides) of the original proteins. With highly specialized technology capabilities and proficiency and expertise of personnel in the field of mass spectrometry, the facility is well-prepared and positioned to serve as a regional, national, and international resource and to foster collaboration in the fast developing field of proteomics and metabolomics.