Cancer Immunology, Inflammation & Tolerance


 

Our group strives to redefine the field of drug design and development. Employing molecular docking, the group identifies bioactive compounds and provides the multi-step synthesis of those top-scoring targets and their novel analogs.

We are working in the field of early-stage drug discovery, developing novel drug candidates and identifying their bioactivity profile. The research work involves synthesis of bioactive linear and cyclic polypeptides and peptidomimetics, nucleosides, conjugates and small heterocyclic scaffolds. In order to identify lead compounds, structure-activity relationships methods are generally employed.

Jain, M., Gamage, N-D., Alsulami, M., Shankar, A., Achyut, B., Angara, K., Harun, M, Rashid, M. H., Iskander, A., Borin, T., Wenbo, Z., Ara, A., Ali, M., Lebedyeva, I., Chwang, W., Guo, A., Bagher-Ebadian, H., Arbab, A. “Intravenous Formulation of HET0016 Decreased Human Glioblastoma Growth and Implicated Survival Benefit in Rat Xenograft Models” 2017, Sci. Reports, 7, 41809.

Booth, L., Albers, T., Roberts, J. L., Tavallai, M., Poklepovic, A., Lebedyeva I. O., Dent, P. “Multi-kinase inhibitors interact with sildenafil and ERBB1/2/4 inhibitors to kill tumor cells in vitro and in vivo”. Oncotarget, 2016, 7(26):40398–40417.

Lebedyeva, I. O., Oliferenko, A. O., Oliferenko, P. V., Hromas, R., Neubert, J., Caudle, M., Castleman, W. L., Altschuler, G. I., Ostrov, D., Hall, C. D., Katritzky, A. R. “Ionic Conjugates of Lidocaine and Sweeteners as Better Tasting Local Anesthetics for Dentistry” J. Mat. Chem. B., 2015, 3, 8492–8498.

Lebedyeva, I. O., Biswas, S., Goncalves, K., Sileno, S. M., Jackson, A. R., Patel, K., Steel, P. J., Katritzky, A. R. “One-Pot Decarboxylative Acylation of N-, O-, S-Nucleophiles and Peptides with 2,2-Disubstituted Malonic Acids”. Chem.: Eur. J., 2014, 20(37), 11695–11698.

Lebedyeva, I. O., Povstyanoy, V. M., Ryabitskii, A. B., Panasyuk, O., Ivahnenko, E., Lozova, V. P., Markevich, I., Allakhverdova, S., Povstyanoy M. V. “Theophyllinopyrimidine Scaffolds Undergo Intramolecular Cyclization Reactions to Form 1,3-Diazepines and Imidazopurines” Eur. J. Org. Chem., 2013, 4594–4606.

Bol'shakov, O., Lebedyeva, I., Katritzky A. “17alpha-Ethynylestradiol Peptide Labeling by "Click" Chemistry” Synthesis, 2012 44, 2926-2932.

2017 Top 10 in 10 Young Professionals to Watch Award, Augusta Magazine