Study Description: The purpose of this study is to examine the relationship between signals of inflammation in the blood, and epigenetic changes (physical changes to DNA, the substance in our cells which contains information we inherited from our parents) in patients with schizophrenia and related disorders. Inflammation is the complex response of the blood vessels to injury,it does not mean infection. There is evidence that signals of inflammation in the blood, which are produced by various immune cells, are associated symptoms in some patients. Epigenetic changes affect the expression of genes (proteins which can predict things like physical appearance and may also be a factor in whether you are at risk for developing certain illnesses or disorders) in the body. There is also evidence that patients with schizophrenia have different epigenetic changes than healthy control subjects. To better understand the relationship between inflammation and epigenetic changes in schizophrenia is an important opportunity that could potentially identify new treatments for this disorder.
Principal Investigator: Brian Miller
Eligibility Criteria: We are looking for males and females age 18-55 with a diagnosis of schizophrenia or schizoaffective disorder that are stable and have not had a psychiatric hospitalization in the past 3 months.
Compensation: Yes, subjects will be compensated.
Compensation Explanation: Subjects will receive a check in the amount of $75 for completing the study visit.
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