Study Description: The nonrandomized study examines the effects of a new form of ECT on mood and thinking known as Focal Electrically-Administered Seizure Therapy (FEAST) in comparison to the traditional form of ECT known as ultrabrief Right Unilateral (RUL) ECT. The new type of ECT treatment known as FEAST attempts to restrict the brain seizure to the frontal lobe thereby reducing the risk of cognitive deficits that might occur with ECT treatment. Patients who are 18-90 years old, have a diagnosis of major depression, have not responded or been intolerant to other depression therapies, and are interested electro-convulsive therapy as a form of treatment for their depressive symptoms may qualify for this study. Patients identified based on their interest in ECT are educated on the type of ECT treatments available to them (i.e., FEAST and RUL ECT). A total of 20 patients will be recruited to receive treatment with FEAST, while a cotemporaneous group of 20 patients will be recruited to receive standard clinical treatment with UB RUL ECT.
Principal Investigator: William McCall
Eligibility Criteria: INCLUSION CRITERIA Age between 18-90 Diagnosis of Major Depressive Disorder Referred for Electroconvulsive Therapy per physician evaluation Exclusion Criteria: No history schizophrenia, schizoaffective disorder, other psychosis, or rapid cycling bipolar disorder History of a central nervous system illness, epilepsy, delerium dementia, or amnesic disorder Alcohol or substance abuse or dependence in the past year Pregnant females
Compensation: Yes, subjects will be compensated.
Compensation Explanation: When the subject attends and participates in the two-, four-, and six-month follow-up procedures, they will be paid $20.00 for each hour of time that they contribute. For each MRI scan the subject will be paid $50.00. If the subject chooses to discontinue their participation they will be paid for the amount of time they have contributed to that point. Payments will be made by check, within 4-6 weeks. If the subject completes these follow-up assessments, which typically involve up to 3 hours, the total compensation would be $180. With two MRI scans at $50 each, the total possible compensation per subject would be $280.
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