Study Description: This project is to study the role of small cell-manufactured particles in human eyes. These particles are released into the clear fluid in the eye. These particles contain many genetic materials. The genetic materials can serve as messengers between different cells in human eyes and may be an indicator of a human eye disorder -- glaucoma. Glaucoma often leads to permanent vision loss and is one of the leading causes of blindness in the US. These particles in human eyes and their genetic content will be analyzed in individuals with or without glaucoma. This study will significantly improve our understanding of glaucoma and will lead to better diagnosis and treatment of this common eye disease.
Principal Investigator: Yutao Liu
Eligibility Criteria: We will include both affected and unaffected subjects. All affected subjects will need to meet the following criteria: 1) at least 35 years old and not showing any secondary known causes for increased eye pressure during eye exam; 2) consistent clinical evidence for vision loss due to nerve damage and no requirement of increased eye pressure. The normal unaffected controls are required to have: 1) at least 40 years old and no parents or siblings affected by glaucoma; 2) low eye pressure with at least two occasions.
Compensation: No, subjects will not be compensated.
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