Study Description: The purpose of this study is to look athow sodium retention after stress effects blood pressure and to find out if this response is due to the direct stimulation of the kidney (the organ that controls salt levels in the body) by the brain. To do this, we will determine if a drug called Prazosin (and alpha adrenergic blocker that has been approved by the Food and Drug Administraton (FDA)) will stop the connection between the brain and the kidney during mental stress and will prevent sodium retention.
Principal Investigator: Gregory Harshfield
Eligibility Criteria: * African American (male or female) * Normotensives (nomal blood pressure) and of good general health; * Not on any prescription medications * Between the ages of 18 and 40 * Not pregant
Compensation: Yes, subjects will be compensated.
Compensation Explanation: SUBJECT PAYMENT Payment will be made using a pre-paid debit card. It works like a bank debit card. We will give you a debit card and each time you receive a payment for participation in this study, the money will be added to the card after each completed visit. You may use this card at any store that accepts credit cards or you can use a bank machine to remove cash. However, there may be fees drawn against the balance of the card for cash withdrawals and inactivity. You will receive letters with additional information on how you can use this card and who to call if you have any questions. Be sure to read these letters, including the cardholder agreement, for details about fees. The debit card system is administered by an outside company. The company, Greenphire, will be given your name and social security number. They will use this information only as part of the payment system. Your information will not be used for any other purposes and will not be given or sold to any other company. Greenphire will not receive any information about your health status or the study in which you are participating. If you are receiving compensation over $100.00 from participating in this study, you will be required to complete a W-9 form. If you are an Augusta University employee, payment will be included in your payroll check. This payment will be subject to Federal and Georgia state withholding taxes as well as FICA tax and will reflect on the W-2 form at calendar year end. Payment received as compensation for participation in research is considered taxable income to the research participant. If payment to an individual exceeds $600 in any one calendar year, Augusta University is required to report this information to the Internal Revenue Service (IRS). Research participant payments to a non-employee of AU exceeding $600 during any calendar year will result in a 1099 (Miscellaneous Income) form being issued to the individual and a copy sent to the IRS. For completing the screening visit, which includes all aspects of the screening described above, you will receive $20.00 which will be added to your debit card. For participating in the testing protocol, you will receive $200.00 for both 7-day testing week for a total of $400.00. In addition to the $400.00, you can earn an extra $20.00 if you win the video game challenge. Since you get to play the video game twice, you could possibly earn $20.00 per game. You will also earn $20.00 more for completing the DEXA/pQCT scans. You can be compensated up to a grand total of $480.00. You will be compensated after each testing visit and the amount due to you will be added to your debit card. You need to understand that you must complete each testing visit in order to be paid. Completion of Screening Visit???????????$20.00 ? Debit Card Completion of Test Week One???????????$200.00 ? Debit Card Win Video Game of Week One ??????????..$20.00 ? Debit Card Completion of Test Week Two?????????........$200.00 ? Debit Card Win Video Game of Week Two ??????????. $20.00 - Debit Card Completion of DEXA/pQCT Scans..................................$20.00 - Debit Card _____________________ ________ Grand Total: $480.00
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