Study Description: The purpose of this study is to better understand why HIV-infected individuals are more prone to oral infections and oral cancers by studying and then comparing the individual immune system and the oral bacteria of HIV-positive and HIV-negative people, with and without oral infections. The study will investigate the oral bacteria and oral immunity in several oral infections and conditions seen commonly in HIV-positive persons, including oral yeast infections, oral warts and oral cancer. Oral bacteria and immune responses, or the lack of an immune system response will be evaluated using oral washes and possibly biopsy of the mouth and will be compared between HIV-positive and HIV-negative individuals with and without oral disease. This will help show the type of immunity present and the type of bacteria present in the mouth in individuals with HIV infection and compared to those individuals that are not HIV positive. It is thought that HIV positive individuals have different bacteria in their mouths and also have a local immune deficiency in their mouth making them more prone to oral infections and to cancers in their mouths and throats.
Principal Investigator: Jose Vazquez
Eligibility Criteria: HIV infected individuals between the ages of 21 and 65 years of age with either the evidence of active OPC infection, oral warts, or oral cancer, HIV positive individual not taking antiretroviral therapy, or an individual at high risk for a sexually transmitted infection.
Compensation: Yes, subjects will be compensated.
Compensation Explanation: Patient will receive cash in the amount of $25.00 for each research-related clinic visit for travel reimbursement. If patient has a biopsy and comes for the follow-up visit, patient will recieve a total of $50.00 in reimbursement.
If you don't see specific studies that interest you, please submit your contact information for future studies.