Study Description: This study is focusing on how a drug called Linaclotide that treats Irritable Bowel Syndrome with constipation, works. We know the drug works, but we are not exactly sure how it works to improve bowel movements and pain associated with IBS-C. The subjects in the study will undergo various tests to see how this drug is helping people.
Principal Investigator: Satish Rao
Eligibility Criteria: People who are 18 to 80 years old who have been diagnosed with IBS-C or suspect they have IBS-C. People who are otherwise healthy, but do not have bowel movements regulary and have pain associated with their constipation. Must not be pregnant or become pregnant. Are not taking any drugs that cause constipation or decrease pain (ex. opiods, morphine, tricyclic antidepressants)
Compensation: Yes, subjects will be compensated.
Compensation Explanation: You will be paid for time, inconvenience, travel and meal-related costs with the amount of $550 for completion of the entire study. Compensation will be pro-rated ($50 for completion of the screening visit, $200 for the second visit, and an additional $300 is compensated for the final (third) visit, which is after completing the 10 weeks of Linaclotide (or Placebo) therapy. Compensation is given at the end of your participation, and is processed upon completion. Reimbursement may be expected approximately 2 weeks after completing your participation in this study. You will be responsible for the costs of transportation to participate in the study.
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