Study Description: Research has suggested that sodium bicarbonate (the active ingredient in baking soda) can slow the rate of decline in kidney function in patients with chronic kidney disease. The way in which sodium bicarbonate works to have this positive effect is not very well understood but it is thought to be acting through the cardiovascular system (parasympathetic activity), lowering inflammation. this potential mechanism of action is yet to be confirmed or investigated in humans. Therefore, the purpose of this pilot study is to explore the mechanism of action of sodium bicarbonate ingestion through parasympathetic activity and markers of inflammation in humans.
Principal Investigator: Ryan Harris
Eligibility Criteria: Inclusion: If you are an adult between the ages of 18-50 who are either lean (BMI < 25 kg/m2) or overweight (BMI ? 30 kg/m2). Exclusion: BMI less than 16 kg/m2 (severely and very severely underweight) or that is greater than 40 kg/m2 (Class III obesity) Evidence of cardiovascular, pulmonary, renal, hepatic, cerebral, or metabolic disease Evidence of pregnancy Using medications that affect vascular tone (i.e., nitrates, etc.) If you are postmenopausal If you have uncontrolled hypertension (treated resting SBP >140 mm Hg or DBP >90 mm Hg) If you are on a restricted salt diet (
Compensation: Yes, subjects will be compensated.
Compensation Explanation: Subject Payment ? Each research subject will receive a total of $100 for completion of this study. ? If subject decides he/she does not want to be in the study anymore, they will be compensated for their time at a rate of $10 U.S. dollars per hour.
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