Adviye Ergul, M.D., PhD.,
Professor, Director Physiology Graduate Program
Office: CA 2094
University of Georgia, Athens, GA,
Postdoctoral Associate, Department of Biochemistry and Molecular Biology, 1995-1996.
University of Miami School of Medicine,
PhD - Department of Biochemistry and Molecular Biology, Miami, FL, 1995.
Ministry of Health, Haseki Hospital, Istanbul, Turkey,
Resident, Clinical Biochemistry, 1987-1990.
The University of Istanbul Cerrahpasa Medical School, Istanbul, Turkey,
1996-1998 - Assistant Research Instructor, Department of Biochemistry and Molecular Biology, University of Georgia.
1998-2000 - Assistant Research Professor, Department of Surgery, Medical University of South Carolina.
2000-2005 - Assistant Professor, Department of Clinical and Administrative Sciences, University of Georgia.
2000-present - Associate Member, Vascular Biology Center, Medical College of Georgia.
2000-present - Adjunct Assistant Professor, Department of Biochemistry & Molecular Biology, University of Georgia.
2001-present - Clinical Assistant Professor, Department of Internal Medicine, Medical College of Georgia.
2001-present - Clinical Assistant Professor, Department of Surgery, Medical College of Georgia.
2005-2006 - Associate Professor, Department of Clinical and Administrative Pharmacy, University of Georgia.
2007 - 2009 - Associate Professor, Department of Physiology, Medical College of Georgia.
2009 - present - Professor, Department of Physiology, Medical College of Georgia
The overall goal of my laboratory is to better understand the regulation of vascular function and structure in diabetes in order to prevent, delay or reverse diabetes-associated complications including stroke and cognitive impairment. In collaboration with Dr. Susan Fagan, we have made the interesting observation that there is significant cerebral neovascularization in type 2 diabetic rats and when ischemia/reperfusion injury occurs, diabetic animals develop bleeding into the brain, a dreaded complication of stroke. Our efforts are focused on how diabetes alters the expression and function of key mediators that are critical for vascular integrity and function. These studies are important to identify potential mechanisms contributing to cognitive decline in diabetes as well as identifying how an ischemic injury superimposed on this existing pathology affect functional outcomes and recovery following stroke. In addition, based on the clinical evidence which suggests that acute hyperglycemic patients suffer the worst outcomes of stroke, in collaboration with Dr. Askiel Bruno from Department of Neurology, we are investigating the mechanisms that mediate greater vascular and neuronal injury in hyperglycemic stroke.
Top. Representative brain images showing increased vascular remodeling and arteriogenesis in type 2 diabetic Goto-Kakizaki (GK) rats.
Bottom. When ischemia reperfusion injury is overlayed on this pathology by temporary middle cerebral artery occlusion, diabetic rats develop significant bleeding into the brain that worsens functional outcomes
Diabetes & Ischemic Brain Injury. This project focuses on the effects of diabetes-induced changes in the microvascular structure and function on increased risk of stroke as well as mechanisms of worsened stroke outcome in diabetes. The project also investigates how bleeding into the brain during stroke can impair the repair process and functional recovery.
Acute Hyperglycemia & Ischemic Brain Injury. This translational project focuses on the mechanisms underlying increased neurovascular injury in hyperglycemic stroke. We specifically focus on the effects of hyperglycemia on cerebrovascular function and integrity. Vascular function studies investigate the mechanisms by which hyperglycemia reduces myogenic tone in both hemispheres of the brain under normoxic and hypoxic conditions. Vascular integrity studies investigate the role of matrix metalloprotease3 (MMP3) in increased bleeding after stroke using different models of experimental stroke and hyperglycemia.
Microvascular Remodeling and Vascular Complications in Obesity and Diabetes: This project seeks to determine the physiological and molecular mechanisms of increased cerebral angiogenesis and arteriogenesis in diabetes and obesity.
Maha Coucha, BPharm - Graduate Student
Sherif Hafez, BPharm - Graduate Student
Zhi Qu - Graduate Student
Weiguo Li, MD, PhD. - Postdoctoral Associate
Mohammed Abdelsaid, PhD - Postdoctoral Associate
Handong Ma - Research Associate
Back Row: Sherif Hafez, Dr. Mohammed Abdelsaid, Dr. Weiguo Li
Front Row: Dr. Roshini Prakash (recent graduate), Maha Coucha, Dr. Adviye Ergul, Handong Ma and Zhi Qu
Adviye Ergul, PI
Georgia Health Sciences University Distinguished Research Faculty Award 2012.
American Heart Association Council on High Blood Pressure Research Leadership Committee
American Heart Association Brain 3 Review Panel Co-Chair
Maha Coucha: Fisher Scientific Excellence in Biomedical Research Award– Medical College of Georgia Graduate Research Day, 2012.
Charlie Norwood VA Medical Center Research Week, 2nd place, Graduate Student Poster Award, 2012.
American Heart Association Greater SouthEast Affiliate, Predoctoral Fellowship, 2012-2014.
Sherif Hafez:Southern Translational and Education Research Conference, runner-up, Graduate Student Poster Award, 2012.
University of Georgia Research Day, 1st place, Poster Presentation, 2012.
Elgebaly MM, Ogbi S Li W, Prakash R, Johnson MH, Mezzetti EM, Bruno A, Fagan SC and Ergul A. Neurovascular outcomes in acute hyperglycemia and diabetes: A comparative analysis in experimental stroke. Trans. Stroke Res., 2:391-398, 2011. PMID: 21909340
Guan W, Somanath PR, Kozak A, Goc A, El-Remessy AB, Ergul A,Johnson MA, Alhusban A, Soliman S, Fagan SC. Vascular protection by angiotensin receptor antagonism involves differential VEGF expression in both hemispheres after experimental stroke. PLoS ONE, 6(9):e24551, 2011. PMID: 21912702
Ergul A, Kelly-Cobbs A, Abdalla M, and Fagan SC. Cerebrovascular complications of diabetes. Endocr Metab Immune Disord Drug Targets, 12(2):148-158, 2012. PMID: 22236022
PrakashR, Shenoy S, El-Remessy A, Kelly-Cobbs A, Stern JE, Dore-Duffy P, Johnson M, FaganSC and ErgulA. Enhanced cerebral but not peripheral angiogenesis in the Goto-Kakizaki model of type 2 diabetes involves VEGF and peroxynitrite signaling. Diabetes, 61(6):1533-1542, 2012. PMID: 22403298
Coucha M, Li W, and Ergul A. Endothelin receptor A antagonism improves large artery vasorelaxation after ischemic stroke.Life Sciences, 91(13-14):676-680, 2012. PMID: 22365958
Switzer JD, Sikora A, Ergul A, Waller JL, Hess DC, Fagan SC. Minocycline prevents IL-6 increase after acute ischemic stroke.Transl Stroke Res, 3(3):363-368, 2012. PMID:23105953
Ergul A, Alhusban A, and Fagan SC. Angiogenesis: A Harmonized Target for Recovery after Stroke. Stroke, 43(8):2270-2274, 2012. PMID: 22618382
Kelly-Cobbs AI, Prakash R, Knight RA, Li W, Ogbi S, Jonhson M and Ergul A. Cerebral myogenic reactivity and blood flow in type 2 diabetic rats: Role of peroxynitrite in hypoxia-mediated loss of myogenic tone. J Pharmacol Exp Ther, 342(2):407-15, 2012. PMID: 22570365
Hoda N, Hill W, Ergul A, Fagan SC, and Hess D. Remote ischemic perconditioning is effective alone and in combination with intravenous tissue plasminogen activator in murine model of embolic stroke. Stroke, 43(10):2794-9, 2012. PMID:22910893
Fagan SC, Lapchak PA, Liebeskind DS, Ishrat T, and Ergul A. Recommendations for Preclinical Research in Hemorrhagic Transformation. Transl Stroke Res. In press.