Amyn M. Rojiani , MD, PhD


 

Department of Pathology, Chairman

Office Phone: (706) 721-2923 
Office Address: BF 104 
E-mail:
 ARojiani@augusta.edu

rojani

Title/Rank

Chairman of Pathology.

Edgar R. Pund Distinguished Chair of Pathology.

Clinical Service Chief of Pathology.

Appointment Date

May 2010

Appointment Type

Full-Time

Education

M.D., University of Karachi, 1982

PhD., University of Medicine and Dentistry of New Jersey, (Now - Rutgers University) 1987

Residency & Fellowships

Residency, University of Medicine and Dentistry of New Jersey, (Now - Rutgers University) 1989 - Anatomic Pathology.

Fellowship, University of British Columbia/Vancouver General Hospital, 1991 - Neuropathology.

Board Certification(s)

Anatomic Pathology / Neuropathology

Major Interests

Research Areas

Research interests include CNS metastasis, matrix metalloproteinases and their inhibitors, vascular targeting agents including combretastatin. Dr. Rojiani's research also focuses on vascular changes and inflammation in Alzheimer's disease.

Selected Publications

TIMP-1 downregulation modulates miR-125a-5p expression and triggers the apoptotic pathway. Ghoshal-Gupta S, Kutiyanawalla A, Lee BR, Ojha J, Nurani A, Mondal A, Kolhe R, Rojiani AM and Rojiani MV: 2018; 9:8941-8956. https://doi.org/10.18632/oncotarget.23832

Entrustable Professional Activities for Pathology: Recommendations From the College of American Pathologists Graduate Medical Education Committee. McCloskey CB, .. Rojiani AM, ..Powell SZ.: Volume: 4 Article published online: June 27, 2017; https://doi.org/10.1177/2374289517714283

The Recent Pathology Residency Graduate Job Search Experience: A Synthesis of 5 Years of College of American Pathologists Job Market Surveys. Gratzinger DA, .. Rojiani AM,.. Powell SZ:  Academic Pathology Arch Pathol Lab Med. 2017 Dec 6. doi: 10.5858/arpa.2017-0207-CP. [Epub ahead of print]

 A randomized phase II study of everolimus in combination with chemoradiation in newly diagnosed glioblastoma: Results of NRG Oncology RTOG 0913. Chinnaiyan P, Won M, Wen PY, Rojiani AM, … Mehta MP. Neuro Oncol. 2017 Nov 6. doi: 10.1093/neuonc/nox209. [Epub ahead of print]

Morphologic and Elemental Analysis of Primary Melanosis of the Dentate Nucleus: Review and Correlation with Neuromelanin. Hopley R, Haller E, Rojiani MV, Rojiani AM:  J Neuropathol Exp Neurol. 76, No. 11, November 2017, pp. 949–956

Vascular morphometric parameters- correlation with histologic grade and VEGF expression in oligodendroglioma. Strickland-Marmol LB, Brem S, Rojiani AM, Rojiani MV:  Am J Cancer Res. 2017 Apr 1;7(4):973-981. eCollection 2017.

  Perceptions of Unprofessional Attitudes and Behaviors: Implications for Faculty Role Modeling and Teaching Professionalism During Pathology Residency. Brissette MD, … Rojiani AM, Powell SZ: Arch Pathol Lab Med. 2017; 141:1394-1401; doi: 10.5858/arpa.2016-0477-CP

  Professionalism in Pathology: A Case-Based Approach as a Potential Educational Tool. Domen R, ….Rojiani AM, Powell SZ:  Arch Pathol Lab Med. Arch Pathol Lab Med. 2017 Feb;141(2):215-219. doi: 10.5858/arpa.2016-0217-CP. Epub 2016 Oct 20. PMID: 27763788

Employer Expectations for Newly Trained Pathologists: Report of a Survey from the Graduate Medical Education Committee of the College of American Pathologists. Post MD, J…Rojiani AM, Tucker JA, Powell SZ:  Arch Pathol Lab Med. 2015 Oct 2. [Epub ahead of print], 2017 Vol 141, 193-202,  PMID:26430810

TIMP-1 inhibits apoptosis in lung adenocarcinoma cells via interaction with Bcl-2. Nalluri S, Ghoshal-Gupta S, Kutiyanawalla A, Gayatri S, Lee BR, Jiwani S, Rojiani AM and Rojiani MV: PLoS One. 2015 Sep 14;10(9):e0137673. doi: 10.1371/journal.pone.0137673. eCollection 2015.PMID:26366732

Assessment and Management of Professionalism Issues in Pathology Residency Training: Results from Surveys and a Workshop by the Graduate Medical Education Committee of the College of American Pathologists. Domen R, …. Rojiani AM, Tucker JA, Powell SZ: Academic Pathology July-September 2015: 1-9

TIMP-1 Overexpression in Lung Carcinoma Enhances Tumor Kinetics and Angiogenesis in Brain Metastasis. Rojiani MV, Ghosal-Gupta S, Kutiyanawalla A, Mathur S, Rojiani AM: J Neuropathol Exp Neurol. 2015 Apr;74(4):293-304..PMID:25756591

Utility and impact of early t(15;17) identification by Fluorescence In-Situ Hybridization (FISH) in clinical decision making for patients in Acute Promyelocytic Leukemia (APL). Kolhe R, Mangaonkar A, Mansour J, Clemmons A, Shaw J, DuPont B, Lwolzack L, Mondal A, Rojiani AM, Jillella AP, Kota V: Int J Lab Hematol. 2015 Aug; 37(4):515-20. Epub 2015 Jan 14.PMID:25639817

Matrix Metalloproteinases-Modulating the Tumor Microenvironment. Wiranowska M, Rojiani AM, Rojiani MV (2015) J Carcinog Mutagen 6:225. doi: 10.4172/2157-2518.1000225

  The indoleamine 2,3-dioxygenase pathway controls complement-dependent enhancement of chemo-radiation therapy against murine glioblastoma. Li M, … Rojiani AM, … Munn DL and Johnson TS: J Immunother Cancer. 2014 Jul 7;2:21. doi: 10.1186/2051-1426-2-21. PMID: 25054064

  Vascular Alterations in Schwannomas. Papiez J, Rojiani MV, Rojiani AM:   Int J Clin Exp Pathol. 2014; 7(7): 4032–4038

  Immunoglobulin G4 related Leptomeningitis: A reversible cause of rapidly progressive cognitive decline. Mehta SH, Switzer JA, Biddinger P, Rojiani AM:   Neurology. 2014 Feb 11;82(6):540-2.

  6p22.3 amplification as a biomarker and potential therapeutic target of advanced stage bladder cancer. ShenH, ……, Rojiani AM, ….. Candace JS.   Oncotarget. 2013 Nov;4 (11):2124-34.

  Vascular development in mouse lung metastases. Salmon HW, Guha A, Rojiani AM, Siemann DW. Am J Cancer Res. 2012;2(5):581-8. Epub 2012

  Tumor-To-Tumor Metastasis: Pathology And Neuroimaging Considerations. Moody P, Murtagh K, Piduru S, Brem S, Murtagh R and Rojiani AM  Int J Clin Exp Pathol 2012;5(4):367-373

Phase I trial of vorinostat combined with bevacizumab and CPT-11 in recurrent glioblastoma. Chinnaiyan P, ..S, Brem S, Yu HM, Rojiani AM, Murtagh R, Pan E: Neuro Oncol. 2012 Jan;14(1):93-100. doi: 10.1093/neuonc/nor187. Epub 2011 Oct 25.

Support of a free radical mechanism for enhanced antitumor efficacy of the microtubule disruptor OXi4503.  Rice L, Pampo C, Lepler S, Rojiani AM, Siemann DW. Microvasc Res. 2011 Jan;81(1):44-51. Epub 2010 Oct 23. PubMed PMID: 20974154; PubMed Central PMCID: PMC3021177.

Matrix Metalloproteases and Their Inhibitors- Friend or Foe: in “ The Tumor Microenvironment.” Rojiani MV, Wiranowska M,  Rojiani AM : Editor: Siemann DW. Wiley and Sons. 2011

Expression of MMP-2 correlates with increased angiogenesis in CNS metastasis of lung carcinoma. Rojiani MV, Alidina J, Esposito N, Rojiani AM. Int J Clin Exp Pathol. 2010 Oct 16;3(8):775-81. PubMed PMID: 21151391; PubMed Central PMCID: PMC2993228.

Current perspectives in the management of hyponatremia: prevention of CPM. Sterns RH, Silver S, Kleinschmidt-DeMasters BK, Rojiani AM. Expert Rev Neurother. 2007 Dec;7(12):1791-7. Review. PubMed PMID: 18052771.

Central and extrapontine myelinolysis: then...and now. Kleinschmidt-Demasters BK, Rojiani AM, Filley CM. J Neuropathol Exp Neurol. 2006 Jan;65(1):1-11.Review. PubMed PMID: 16410743.

Dynamic complexity of the microglial activation response in transgenic models of amyloid deposition: implications for Alzheimer therapeutics. .Morgan D, Gordon MN, Tan J, Wilcock D, Rojiani AM. J Neuropathol Exp Neurol. 2005 Sep;64(9):743-53. Review. PubMed PMID: 16141783.

The vascular disrupting agent ZD6126 shows increased antitumor efficacy and enhanced radiation response in large, advanced tumors. Siemann DW, Rojiani AM. Int J Radiat Oncol Biol Phys. 2005 Jul 1;62(3): 846-53. PubMed PMID: 15936569

Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage. Wilcock DM, Rojiani A, Rosenthal A, Subbarao S, Freeman MJ, Gordon MN, Morgan D. J Neuroinflammation. 2004 Dec 8;1(1):24. PubMed PMID: 15588287; PubMed Central PMCID: PMC539292.

Inhibition of angiogenesis by Abeta peptides. Paris D, …. Rojiani AM, Crawford F, Sebti SM, Mullan M. Angiogenesis. 2004;7(1):75-85. PubMed PMID: 15302999

Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition. Wilcock DM, Rojiani A, Rosenthal A, Levkowitz G, Subbarao S, Alamed J, Wilson D, Wilson N, Freeman MJ, Gordon MN, Morgan D. J Neurosci. 2004 Jul 7;24(27):6144-51. PubMed PMID: 15240806.

Antitumor efficacy of conventional anticancer drugs is enhanced by the vascular targeting agent ZD6126.  Siemann DW, Rojiani AM.. Int J Radiat Oncol Biol Phys. 2002 Dec 1;54(5):1512-7. PubMed PMID: 12459379

Enhancement of radiation therapy by the novel vascular targeting agent ZD6126. Siemann DW, Rojiani AM. Int J Radiat Oncol Biol Phys. 2002 May 1;53(1):164-71. PubMed PMID: 12007956.

Activity of the vascular targeting agent combretastatin A-4 disodium phosphate in a xenograft model of AIDS-associated Kaposi's sarcoma.Rojiani AM, Li L, Rise L, Siemann DW. Acta Oncol. 2002;41(1):98-105. PubMed PMID: 11990526

Preclinical evaluations of therapies combining the vascular targeting agent combretastatin A-4 disodium phosphate and conventional anticancer therapies in the treatment of Kaposi's sarcoma. Li L, Rojiani AM, Siemann DW. Acta Oncol. 2002;41(1):91-7. PubMed PMID: 11990525.

Vascular targeting agents enhance chemotherapeutic agent activities in solid tumor therapy. Siemann DW, Mercer E, Lepler S, Rojiani AM. Int J Cancer. 2002 May 1;99(1):1-6. PubMed PMID: 11948484

Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice. Jantzen PT, .., Rojiani AM, Coppola D, Morgan D, Gordon MN. J Neurosci. 2002 Mar 15;22(6):2246-54. PubMed PMID: 11896164.

CD40 is expressed and functional on neuronal cells. Tan J, Town T, Mori T, Obregon D, Wu Y, DelleDonne A, Rojiani A, Crawford F, Flavell RA, Mullan M. EMBO J. 2002 Feb 15;21(4):643-52. PubMed PMID: 11847112; PubMed Central PMCID: PMC125862.

 

For a complete listing of all publications, see Dr. Rojiani's work at PubMed.