Ravindra Kolhe, MD, PhD


Department of Pathology, Section of Anatomic Pathology

kolhe

Office Phone: (706) 721-2925 
Office Address: BF-212/BAE-2576
E-mail: rkolhe@augusta.edu

Title/Rank
Associate Professor of Pathology.

Associate Director Residency Program.

Medical Director of Cytogentics Laboratory at AUMC.

Director, Georgia Esoteric & Molecular Laboratory at Augusta University.

Appointment Date
July 2012

Appointment Type
Full Time

Education
MBBS, 2001: Mahatma Gandhi Medical College, Aurangabad, India.
PhD, 2006; Mississippi State University, Starkville, MS.

Residency
2008 - 2012, Resident, Pathology AP/CP, Augusta University.

2011 - 2012, Chief Resident, Augusta University.

2007 - 2008, Post-Doctoral Fellowship, Augusta University

01/14 - 12/14, Fellowship, Teaching Scholars Tract, EII, Augusta University

Care Philosophy

  • As a Molecular and Genetic Pathologist, I am actively engaged in molecular and cytogenetic evaluation of patient samples as a part of the multi- disciplinary clinical team treating patients. It is my goal to render not only the most accurate diagnosis but also to provide and develop the highest quality predictive and prognostic tests as a part of personalized medicine. This approach helps my clinical colleagues take the best possible care of the patient while at the same time advancing our scientific knowledge in these areas. My clinical work involves molecular evaluation of various pathologic disorders and malignancies.
  • As a Laboratory and Medical Director I am actively engaged in cytogenetics evaluation of hematological malignancies as a part of the multi- disciplinary clinical team treating patients. Molecular analysis can identify the cause of disease, diagnose disease, and contribute to improved medical care, medical education, and research. I am also actively involved in medical and graduate education and translation pathology research.


Major Interests 

  • Surgical Pathology. 
  • Breast Pathology. 
  • Molecular Pathology and Cancer Cytogenetics.
  • Pathology Informatics

Certification and Licensures

  • Diplomate of the American Board of Pathology: Anatomic and Clinical Pathology.
  • Fellow College of American Pathology (FCAP).
  • Fellow American Society of Clinical Pathology (FASCP).
  • Georgia State Medical License (Georgia State Board of Medical Examiners): Active and unrestricted.
  • Clinical Laboratory Director License (CLIA), Georgia Department of Community Health, State of Georgia.

Research Interests

Devising and development of new molecular laboratory tests (LDT)s: 
Identifying newer validated platforms and incorporating them in development of advanced molecular testing in human diseases. This will offer a large variety of molecular markers for diagnosis and predicting therapeutic response in tumors. Long-term goal is to develop molecular (mi-RNA/m-RNA/DNA/protein) based test panels aiding in the differential diagnosis, prognosis, therapeutic response and management of various diseases/malignancies.

Teaching Areas

  • Medical Students: Phase II pathology – Cytogenetics of myeloproliferative neoplasms, Breast pathology, Surgical Pathology.
  • Phase I Cellular and Molecular Basis of Medicine module- Personalized Medicine
  • Pathology Residents: Molecular Pathology, Surgical Pathology, Cancer Cytogenetics, Breast Pathology, Lab Management and Pathology informatics.
  • Hematology-oncology Fellows: Molecular Pathology, Cancer Cytogenetics.
  • Med Tech students - Clinical Molecular Methods Lab, Clinical Molecular Methods Internship CLSC 7990
  • PRIDE Summer Institute: Molecular Diagnostics.

Selected Publications

  1. Kolhe R, Hunter M, Liu S, Jadeja RN, Pundkar C, Mondal AK, Mendhe B, Drewry M, Rojiani MV, Liu Y, Isales CM. Gender-specific differential expression of exosomal miRNA in synovial fluid of patients with osteoarthritis. Scientific Reports. 2017 May 17;7(1):2029.
  1. Islam, B.N., Sharman, S.K., Hou, Y., Bridges, A.E., Singh, N., Kim, S., Kolhe, R., Trillo-Tinoco, J., Rodriguez, P.C., Berger, F.G. and Sridhar, S., 2017. Sildenafil suppresses inflammation-driven colorectal cancer in mice. Cancer Prev Res May 3 2017 DOI: 10.1158/1940-6207.CAPR-17-0015.
  1. Ouzounova, M., Lee, E., Piranlioglu, R., El Andaloussi, A., Kolhe, R., Demirci, M. F., ... & Thangaraju, M. (2017). Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade.Nature communications, 8, 14979.
  1. Kapil, Shweta, Bal Krishan Sharma, Mallikarjun Patil, Sawsan Elattar, Jinling Yuan, Steven X. Hou, Ravindra Kolhe, and Ande Satyanarayana. "The cell polarity protein Scrib functions as a tumor suppressor in liver cancer."Oncotarget 8, no. 16 (2017): 26515-26531.
  1. Burke, J., Hunter, M., Kolhe, R., Isales, C., Hamrick, M., & Fulzele, S. (2016). Therapeutic potential of mesenchymal stem cell based therapy for osteoarthritis.Clinical and translational medicine, 5(1), 27.
  1. Pathania, R., Ramachandran, S., Mariappan, G., Thakur, P., Shi, H., Choi, J.H., Manicassamy, S., Kolhe, R., Prasad, P.D., Sharma, S. and Lokeshwar, B.L., 2016. Combined inhibition of DNMT and HDAC blocks the tumorigenicity of cancer stem-like cells and attenuates mammary tumor growth.Cancer research, 76(11), pp.3224-3235.
  1. Noonepalle, S. K., Gu, F., Lee, E. J., Choi, J. H., Han, Q., Kim, J., ... & Kolhe, R. (2017). Promoter Methylation Modulates Indoleamine 2, 3-Dioxygenase 1 Induction by Activated T Cells in Human Breast Cancers.Cancer Immunology Research, 5(4), 330-344
  1. Sivaprakasam, S., Gurav, A., Paschall, A.V., Coe, G.L., Chaudhary, K., Cai, Y., Kolhe, R., Martin, P., Browning, D., Huang, L. and Shi, H., 2016. An essential role of Ffar2 (Gpr43) in dietary fibre-mediated promotion of healthy composition of gut microbiota and suppression of intestinal carcinogenesis.Oncogenesis, 5(6), p.e238.
  1. Rajneesh Pathania, Sabarish Ramachandran, Gurusamy Mariappan, .., Ravindra Kolhe, .., Vadivel Ganapathy, and Muthusamy Thangaraju :Combined inhibition of DNMT and HDAC blocks the tumorigenicity of cancer stem-like cells and attenuates mammary tumor growth.Cancer Res canres.2249.2015; Published Online First April 5, 2016; doi:10.1158/0008-5472.CAN-15-2249
  1. Sharma BK, Kolhe R, Black SM, Keller JR, Mivechi NF, Satyanarayana A. Inhibitor of differentiation 1 transcription factor promotes metabolic reprogramming in hepatocellular carcinoma cells. FASEB J. 2016 Jan; 30(1):262-75. doi: 10.1096/fj.15-277749. Epub 2015 Sep 1. PubMed PMID: 26330493; PubMed Central PMCID: PMC4684534.
  1. Wankhade UD, Shen M, Kolhe R, Fulzele S. Advances in Adipose-Derived Stem Cells Isolation, Characterization, and Application in Regenerative Tissue Engineering. Stem Cells Int. 2016; 2016:3206807. doi: 10.1155/2016/3206807. Epub 2016 Feb 11. Review. PubMed PMID: 26981130; PubMed Central PMCID: PMC4766348.
  1. Mangaonkar A, Xu H, Mohsin J, Mansour J, Chintalapally R, Keen R, Mondal AK, DeRemer D, Clemmons AB, Clark SM, Shah A, Jillela A, Kolhe R, Kota V. Prognostic value of complete remission with superior platelet counts in acute myeloid leukemia. J Community Support Oncol. 2016 Feb;14(2):66-71. doi:10.12788/jcso.0231. PubMed PMID: 26955659.
  1. Bhatta A, Sangani R, Kolhe R, Toque HA, Cain M, Wong A, Howie N, Shinde R, Elsalanty M, Yao L, Chutkan N, Hunter M, Caldwell RB, Isales C, Caldwell RW, Fulzele S. Deregulation of arginase induces bone complications in high-fat/high-sucrose diet diabetic mouse model. Mol Cell Endocrinol. 2016 Feb 15;422:211-20.doi: 10.1016/j.mce.2015.12.005 . Epub 2015 Dec 17. PubMed PMID: 26704078.
  1. Burke J, Kolhe R, Hunter M, Isales C, Hamrick M, Fulzele S. Stem Cell-Derived Exosomes: A Potential Alternative Therapeutic Agent in Orthopaedics. Stem Cells Int. 2016; 2016:5802529. doi: 10.1155/2016/5802529. Epub 2016 Jan 19. Review. PubMed PMID: 26904130; PubMed Central PMCID: PMC4745815.
  1. Jalnapurkar, S., Mangaonkar, A., Mondal, A., Burke, J., Fulzule, S., & Kolhe, R. (2015). miRNA in Pathophysiology of Peripartum Cardiomyopathy (PPCM): A Systemic Review. Journal of Clinical & Experimental Cardiology, 2015.
  1. Jalnapurkar, S., Mangaonkar, A., Mondal, A., Burke, J., Fulzele, S., & Kolhe, R. Journal of Hypertension and cardiology, 2015, DOI: 10.14302/issn.2329-9487.jhc-15-677.
  1. Sangani, Rajnikumar, Sudharsan Periyasamy-Thandavan, Ravindra Kolhe….Sadanand Fulzele. "MicroRNAs-141 and 200a regulate the SVCT2 transporter in bone marrow stromal cells." Molecular and Cellular Endocrinology. 2015 Jan 21. pii: S0303-7207(15)00011-8.
  1. Sangani, R., Periyasamy-Thandavan, S., Pathania, R., Ahmad, S., Kutiyanawalla, A., Kolhe, R. ... & Fulzele, S. (2015). The crucial role of vitamin C and its transporter (SVCT2) in bone marrow stromal cell autophagy and apoptosis. Stem cell research, 15(2), 312-321.
  1. Kolhe, R., A. Mangaonkar A, Mansour J, Clemmons A, Shaw J, Dupont B, Walczak L, Mondal A, Rojiani A, Jillella A, Kota V. Utility and impact of early t(15;17) identification by Fluorescence In Situ Hybridization (FISH) in clinical decision making for patients in Acute Promyelocytic Leukemia (APL). Int J Lab Hematol. 2015 Aug;37(4):515-20. doi: 10.1111/ijlh.12326. Epub 2015 Jan 14. PubMed PMID: 25639817.
  1. Kota V, Clemmons A, Chand A, Simmons J, Mansour J, Kolhe R, Jillella A. Congestive heart failure during induction with anthracycline-based therapy in patients with acute promyelocytic leukemia. J Community Support Oncol. 2014 Nov;12(11):390-3. doi: 10.12788/jcso.0084. PubMed PMID: 25856011.
  1. Kolhe R, Reid MD, Lee JR, Cohen C, Ramalingam P. Immunohistochemical expression of PAX5 and TdT by Merkel cell carcinoma and pulmonary small cell carcinoma: a potential diagnostic pitfall but useful discriminatory marker. Int J Clin Exp Pathol. 2013;6(2):142-7. Epub 2013 Jan 15. PubMed PMID: 23329999; PubMed Central PMCID: PMC3544244.
  1. Kolhe R., Bollage R, Cook L. 'Lookbacks, Recalls, and Market Withdrawals.’ (Manuscript ID CHKS-2010-06-0043-TM, July 2011 Transfusion Medicine series).
  1. Rao, Rekha, Srilatha Nalluri, Ravindra Kolhe, Yonghua Yang, Warren Fiskus, Jianguang Chen, Kyungsoo Ha et al. "Treatment with panobinostat induces glucose-regulated protein 78 acetylation and endoplasmic reticulum stress in breast cancer cells."Molecular cancer therapeutics 9, no. 4 (2010): 942-952.
  2. Chen, Jianguang, Warren Fiskus, Kelly Eaton, Pravina Fernandez, Yongchao Wang, Rekha Rao, Pearl Lee, R Joshi, R Kolhe et al. "Cotreatment with BCL-2 antagonist sensitizes cutaneous T-cell lymphoma to lethal action of HDAC7-Nur77–based mechanism." Blood 113, no. 17 (2009): 4038-4048.

For a complete listing of all publications, see Dr. Kolhe's work here.