Stress Related Mechanisms of Hypertension Risk                                                                                               7/1/2002 – 2/28/2019
PI:  Gregory A. Harshfield                                                                                             
NIH, National Heart Lung and Blood Institute

The major objectives of this program are to 1) define mechanisms that promote hypertension induced by stress, 2) determine the regulation of these mechanisms in high-risk populations, 3) translate findings between animal and human studies, and 4) translate our research into patient populations.  No scientific or financial overlap.  However, we will utilize samples obtained in this study in Aim 1 of the proposed application.

Co-Investigators: Y. Dong, R. Harris, X. Wang

The Role of Endothelin-1 in Sickle Cell Disease                                                                                                 09/2013 - 05/2018
Co-PIs: Abdula Kutlar and David Pollock
NIH, National Heart Lung and Blood Institute

The goal of this project is to test the hypothesis that endothelin-1 contributes to inflammation, vascular complications, and pain in sickle cell disease.

Co-Investigator: Ryan A. Harris

Vitamin K to Slow Progression of Dyslipidemia and Diabetes Risk                                                              07/2016 – 06/2018

PI: Norman Pollock  
American Heart Association        

Co-Investigator: Catherine Davis 

Longitudinal assessment of exercise capacity and vascular function in patients with CF                      06/2015 - 07/2017
PI: Ryan A. Harris
Vertex Pharmaceuticals Investigator Initiated Grant

The major goal of this project is to document exercise capacity and vascular function in homozygous DF508del patients with CF before the launch of ivacaftor/lumacaftor combination therapy.

Mechanism for vascular dysfunction and exercise intolerance in CF                                                          01/2015 – 12/2017
PI: Ryan A. Harris  
Cystic Fibrosis Foundation Clinical Research Award        

The major goal of this project is to identify oxidative stress as a mechanism that contributes to vascular dysfunction and exercise intolerance in CF.

Bad to the Bone: Age-related Increases in Serum SDF-1 Leads to Bone Loss with Age                            10/2013 – 09/2017
PI: William Hill 
Veterans Affairs Merit Award        

Co-Investigator: Norman Pollock