Selected Recent Publications

R.-S. Woo*, X.M. Li*, Y. Tao, E. Carpenter-Hyland, Y.Z. Huang, J. Weber, H. Neiswender, X..-p. Dong, J. Wu, M. Gassmann, C. Lai, W.-C. Xiong, T.-M. Gao1, L. Mei1. Neuregulin-1 Enhances Depolarization-Induced GABA Release. Neuron 54:599-610, 2007 (Highlighted in Neuron 54:495-497, 2007; Nature 448:263, 2007 and Nature Rev. Neurosci., 8:492, 2007). (*, co-contributing; 1, co-correspondence).

 B. Zhang, S. Luo, Q. Wang, T. Suzuki, W.C. Xiong, Lin Mei. LRP4 serves as a coreceptor of agrin. Neuron 60:285-297, 2008 (highlighted in Nature 455:1153, 2008;Nature Rev. Neurosci. 9:886, 2008; Neuron, 60:526, 2008).

 S. Luo, B. Zhang, X.-p. Dong, Y. Tao, A. Ting, Z. Zhou, J. Meixiong, J. Luo, F.C.A. Chiu, W.C. Xiong, L. Mei. HSP90β Regulates Rapsyn Turnover and Subsequent AChR Cluster Formation and Maintenance. Neuron 60:97-110, 2008. (Highlighted at Faculty 1000, DOI: 10.3410/f.1141890.598995)

 L. Wen1, Y.S. Lu1, X. Zhu1, X.M. Li, R.-S. Woo, Y.-J. Chen, D.-M. Yin, C. Lai, A. Vazdarjanova, W.C. Xiong, and L. Mei. Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons. Proc. Nat. Acad. Sci. USA 107:1211- 1216, 2010.

 B. Zhang, J.S. Tzartos, M. Belimezi, S. Ragheb, B. Bealmear, R.A. Lewis, W.C. Xiong, R.P. Lisak, S.J. Tzartos, Lin Mei. Autoantibodies to LRP4 in double seronegative myasthenia gravis patients. Archive Neurol. 69:445-451, 2012. (Highlighted by Editorial, same issue, Archive Neurol., 2012)

 Y. Zong, B. Zhang, S. Gu, K. Lee, J. Zhou, G. Yao, D. Figueiredo, K. Perry, L. Mei* and Rongsheng Jin*. Structural basis of neuron-specific regulation of postsynaptic differentiation. Genes & Development. 26:247-258, 2012 (Cover) (*, cocorrespondence).

 H.T. Wu, Y.S. Lu, C.Y. Shen, W.C. Xiong, L. Mei. Distinct roles of muscle and motoneuron LRP4 in neuromuscular junction formation. Neuron, 75:94-107, 2012.

Y. Tao*, Y. Chen*, C. Shen*, Z. Luo, C.R. Bates, D. Lee, S. Marchetto, T.-M. Gao, J.-P. Borg, W.C. Xiong, Lin Mei. Erbin interacts with TARP gamma-2 for surface expression of AMPA receptors in cortical interneurons. Nature Neurosci. 16:290-299, 2013. (*, cofirst)

 D.M. Yin*, Y.J. Chen*, Y.S. Lu, J.C. Bean, A. Sathyamurthy, C.Y. Shen, X.H. Liu, T.W. Lin, C.A. Smith, W.C. Xiong, and L. Mei. Reversal of schizophrenia-like deficits in neuregulin 1 transgenic mice. Neuron 78:644-657, 2013. (Highlighted by Preview, Neuron 78:577, 2013) PMID: 23719163.

 C. Shen*, B. Zhang*, Y. Lu*, D. Figueiredo, H. Wu, B. Arnab, W.C. Xiong and L. Mei. Immunization with LRP4 induces myasthenia gravis in mice. J. Clin. Invest. 123:5190–5202, 2013.

 Lu,* X.-D. Sun,* F.-Q. Hou, F. Liu, L.L. Bi, D.M. Yin, Y.J. Chen, J. Bean, H.F. Jiao, X. Liu, B.M. Li, W.C. Xiong, T.M. Gao** and L. Mei**. Maintenance of GABAergic activity by neuregulin 1/ErbB4 in amygdala for fear conditioning memory. Neuron 84:835-846, 2014 (*, co-first; **, co-correspondent)

 H. Wu*, A. Barik*, Y. Lu, C. Shen, A. Bowman, L. Li, A. Sathyamurthy, T.W. Lin, W.C. Xiong, and L. Mei. Slit2 as a β-catenin/Ctnnb1-dependent retrograde signal for presynaptic differentiation. eLife 4:e07266, 2015 (*, co-first)

 X.D. Sun,*,** L. Li*, F. Liu, Z.H. Huang, J.C. Bean, H.F. Jiao, A. Barik, S.M. Kim, H. Wu, Shen, Y. Tian, T.W. Lin, R. Bates, A. Sathyamurthy, Y.J. Chen, D.M. Yin, L. Xiong, H.P. Lin, J.X. Hu, B.M. Li, T.M. Gao, W.C. Xiong, Lin Mei**. Lrp4 in astrocytes modulates glutamatergic transmission. Nature Neuroscience 19:1010-1018, 2016 (*, equal contributing; **, corresponding)

 Li,* Y. Cao,* H. Wu, X. Ye, Z. Zhu, G. Xing, C. Shen, A. Barik, B. Zhang, X. Xie, W. Zhi, L. Gan, H. Su, W.C. Xiong, L. Mei. Enzymatic activity of the scaffold protein rapsyn for synapse formation. Neuron (in press). (*, equal contributing)

 Selected recent reviews:

Mei and W.C. Xiong, Neuregulin-1 signaling in neural development, synaptic plasticity and schizophrenia. Nature Rev. Neurosci. 9:437-452, 200

Wu, Wen C. Xiong, L. Mei. To build a synapse: Signaling pathways in neuromuscular junction assembly. Development 137:1017-1033, 2010

 Mei and K.-A. Nave, A neuregulin and ErbB network in the nervous system. Neuron 83:27-49, 2014

 

Contact Us

Department of Neuroscience & Regenerative Medicine

   Health Sciences Campus
       CA-4006
   1120 15th Street
       Augusta, GA 30912
   706-721-8775     
   706-434-6432