Assistant Professor, Department of Neuroscience and Regenerative Medicine
PhD., Dalian, China, 1997
1120 15th Street, CA-4054A
Augusta, GA 30912
Our research interests are stem cell biology and neurodevelopment. We are particularly interested in the molecular mechanisms regulating stem cell pluripotency (the ability to form any tissue lineages), self renewal, differentiation, and survival, and their implications in induced pluripotent stem (iPS) cells generation and clinical application. Current projects include utilization of stress-adaptation response in regenerative medicine for treatment neurological disorders, such as Alzheimer's disease and Stroke; and molecular chaperone regulation of stem cell pluripotency.
Guanghu Wang*, Kannan Krishnamurthy, Dantera Tangpisuthipongsa. Dose dependent induction of cell protection by 17-AAG in mouse neural progenitor cells. Journal of Neurochemistry, accepted 2011. (* corresponding author)
Wang G, Bieberich E. Prenatal alcohol exposure triggers ceramide-induced apoptosis in neural crest-derived tissues concurrent with defective cranial development. Cell Death Dis, May, 2010, 1: e46; doi:10.1038/cddis.
Wang G, Krishnamurthy K, Bieberich E. Regulation of primary cilia formation by ceramide. J Lipid Res. 2009 Apr 16. [Epub ahead of print]
Wang G, Krishnamurthy K, Umapathy NS, Verin AD, Bieberich E. The carboxyl-terminal domain of atypical protein kinase Czeta binds to ceramide and regulates junction formation in epithelial cells. J Biol Chem. 2009 May 22; 284(21):14469-75. Epub 2009 Mar 20.
Guanghu Wang, Kannan Krishnamurthy, Ying-Wei Chiang, and Erhard Bieberich. Role of ceramide in regulating neuroprogenitor cell motility and mouse brain organization, J Neurochemistry. 2008 Jun 2.
Guanghu Wang, Jeane Silva, Somsankar Dasgupta, and Erhard Bieberich. Long-chain ceramide is elevated in presenilin 1 (PS1M146V) mouse brain and induces apoptosis in ps1 astrocytes, Glia, Glia. 2008 Mar;56(4):449-56.
Sachiko Homma*, Xiongjie Jin*, Guanghu Wang*, Naxin Tu*, Jinna Min, Nathan Yanasak and Nahid F. Mivechi. Demyelination, astrogliosis, and accumulation of ubiquitinated proteins, hallmarks of CNS disease in hsf1-deficient mice. J Neurosci. 2007 Jul 25; 27(30):7974-86. (* equal contribution)
Kannan Krishnamurthy*, Guanghu Wang*, Jeane Silva, Brian Condie, and Erhard Bieberich. Ceramide regulates AIF-dependent apoptosis and atypical PKC?/?-mediated cell polarity in ES cell and primitive ectoderm cells: a novel function of sphingolipids in embryonic morphogenesis. J Biol Chem. 2007 Feb 2; 282(5):3379-90. Epub 2006 Nov 14. (* equal contribution)
Guanghu Wang, Jeane Silva, and Bieberich A novel isoform of prostate apoptosis response 4 (PAR-4) that co-distributes with F-actin and prevents apoptosis in neural stem cells. Apoptosis. 2006 Mar; 11(3):315-25.
Guanghu Wang, Silva J, Krishnamurthy K, Tran E, Condie BG, Bieberich E. Direct binding to ceramide activates PKCzeta prior to the formation of a pro-apoptotic complex with PAR-4 in differentiating stem cells. J Biol Chem. 2005 Jul 15; 280(28): 26415-24. Epub 2005 May 18.