Nilkantha Sen, PhD


Nilkantha Sen

Assistant Professor
Department of Neuroscience and Regenerative Medicine
Department of Neurology

PhD, Indian Institute of Chemical biology, CSIR, Jadavpur University, 2006
Post Doc, Johns Hopkins Medical School, laboratory of Solomon Snyder, 2012

Telephone: 706-721-8185
Fax: 706-434-7097 or 706-721-8685
Email: nsen@augusta.edu

Mailing Address:
Augusta University
DNRM
1120 15TH Street
CA-2018
Augusta, GA 30912

Research Interests

The major focus of my laboratory is to study Traumatic Brain Injury (TBI) andAlzheimer's disease (AD). TBI is a major cause of morbidity and mortality and it affects more than 1.7 million people in the US per year. On the other hand, one in eight older Americans has AD and it is the sixth-leading cause of death in the United States. Both TBI and AD leads to neuronal cell death, inflammation and astrocytic activation those results in major changes in physical and mental health in individuals. Unfortunately, there is no treatment is available to treat both life-threatening disorders. In our laboratory we study the influence of neuro-gasotransmitters like Nitric Oxide (NO), Hydrogen Sulfide (H2S) or Carbon monooxide (CO) on major characteristics of TBI and AD. Our study will provide the framework to design a novel therapeutic strategy to combat against both TBI and AD.

Selected Publications

Mir S, Sen T, Sen N Cytokine-induced GAPDH sulfhydration effects PSD95 degradation and memory (2014) Molecular Cell 56,786. 

Kapoor S, Kim SM, Farook JM, Mir S, Saha R, Sen N. Foxo3a Transcriptionally up-regulates AQP4 and induces cerebral edema following Traumatic Brain Injury (2013) Journal of Neuroscience, 33, 17398.

Farook JM, Shields J, Tawfik A, Markand S, Sen T, Smith SB, Brann D, Dhandapani KM, Sen N. GADD34 induces cell death through inactivation of Akt following traumatic brain injury (2013). Cell Death And Disease., 4:e754.

Xu R, Serritella AV, Sen T, Farook JM, Sedlak TW, Baraban J, Snyder SH, Sen N. Behavioral effects of cocaine mediated by nitric oxide-GAPDH transcriptional signaling (2013). Neuron; 78, 623-30.

Xu R, Paul BD, Smith DR, Tyagi R, Rao F, Khan AB, Blech DJ, Vandiver MS, Harraz MM, Guha P, Ahmed I, Sen N, Gallagher M, Snyder SH. Inositol polyphosphate multikinase is a transcriptional coactivator required for immediate early gene induction. Proc. Natl. Acad. Sci. U S A. (2013).

Xu R*, Sen N*, Paul BD, Snowman AM, Rao F, Vandiver MS, Xu J, Snyder SH. Inositol polyphosphate multikinase is a coactivator of p53-mediated transcription and cell death (2013). Science Signaling, ra22. (*equal contribution).

Vandiver SM, Paul BD, Xu R, Karuppagounder S, Rao F, Snowman AM, Ko SH, Yun Il Lee, Dawson VL, Dawson TM, Sen N* and Snyder SH* (2013) Sulfhydration mediates neuroprotective actions of parkin. Nature Communications. 4, 1626. (*co-senior author)

Sen N, Paul BD, Gadalla MM, Mustafa AK, Sen T, Xu R, Kim S and Snyder SH. (2012) Hydrogen sulfide-linked sulfhydration of NF-?B mediates its anti-apoptotic actions. Molecular Cell 45,13-24. (Published as Issue Highlights in this issue and highlighted in Nature Chemical Biology in News and Views and selected as Editor's Choice in Science Signaling).

Sen N and Snyder SH. (2011) Neurotrophin mediated degradation of histone methyltransferase SUV39H1 by S-nitrosylation cascade regulates neuronal differentiation. Proceedings of the National Academy of Sciences of the United States of America 108, 20178-83.

Sen N, Hara MR, Kornberg MD, Cascio MB, Bae BI, Shahani N, Thomas B, Dawson TM, Dawson VL, Snyder SH, Sawa A.(2008) Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis. Nature Cell Biology. 10, 866-873. (selected as Editor's Choice in Science Signaling).

Sen N, Hara MR, Ahmad AS, Cascio MB, Kamiya A, Ehmsen JT, Hester L, Dore S, Snyder SH, Sawa A.(2009) GOSPEL: a novel neuroprotective protein that binds to GAPDH upon S-nitrosylation. Neuron. 63, 81-91. (Published as Featured Article in this issue).

Kornberg MD, Sen N, Hara MR, Juluri KR, Nguyen J, Snowman AM, Law L, Hester LD, Snyder SH. (2010) GAPDH Mediates Nitrosylation of Nuclear Proteins. Nature Cell Biology, 12, 1094-100.

Mustafa AK, Gadalla MM, Sen N, Kim S, Mu W, Gazi SK, Barrow RK, Yang G, Wang R, Snyder SH. (2009) H2S signals through protein S-sulfhydration. Science Signaling. 2:ra72.

Sen T, Sen N, Huang Y, Sinha D, Luo Z, Ratovitski E, and Sidransky D. (2012) Tumor protein p63/nuclear factor kappa-B feedback loop in regulation of cell death. Journal of Biological Chemistry 286, 43204-43213.

Sen T, Sen N, Brait M, Begum S, Chatterjee A, Hoque MO, Sidransky D (2011) DeltaNp63alpha confers tumor cell resistance to cisplatin treatment through a transcriptional regulation of AKT. Cancer Research, 71, 1167-1176.

Sen N, Banerjee B, Das BB, Ganguly A, Sen T, Pramanik S, Mukhopadhyay S, Majumder HK. (2007) Apoptosis is induced in leishmanial cells by a novel protein kinase inhibitor withaferin A and is facilitated by apoptotic topoisomerase I-DNA complex. Cell Death and Differentiation. 14, 358-367.

Sen N, Das BB, Ganguly A, Mukherjee T, Bandyopadhyay S, Majumder HK. (2004) Camptothecin-induced imbalance in intracellular cation homeostasis regulates programmed cell death in unicellular hemoflagellate Leishmania donovani. Journal of Biological Chemistry. 279, 52366-52375.

Sen N, Das BB, Ganguly A, Mukherjee T, Tripathi G, Bandyopadhyay S, Rakshit S, Sen T, Majumder HK.(2004) amptothecin induced mitochondrial dysfunction leading to programmed cell death in unicellular hemoflagellate Leishmania donovani. Cell Death and Differentiation. 11, 924-936.

Reviews

Sen N, Snyder SH.Protein modifications involved in neurotransmitter and gasotransmitter signaling.(2010) Trends in Neurosciences. 33, 493-502.

Sen N, Majumder HK. Mitochondrion of protozoan parasite emerges as potent therapeutic target: exciting drugs are on the horizon. (2008) Current Pharmaceutical Designs. 14, 839-846.