Name:Dr. Pamela Shiao
Department: College of Nursing, Research
Title:Genomics and Bioinformatics
Description: As part of preliminary work to build the long range research program, the objective
of this phase of effort is to pilot testing the optimal dietary habits for healthy
epigenetics in the family context to prevent chronic health conditions for various
racial‐ethnic groups. The secondary aims are to examine the differences on the common
genotypes, proteomics and metabolomics related to chronic diseases for various racial‐ethnic
groups. In addition, behavioral risk factors on folate levels, inflammation markers
including homocysteine levels, methylation status, smoking status, and alcohol use
will be examined for various epigenetics pathways and subgroups.
Methods Using family context and family members as controls, comparing intervention
and control groups, this is a family based randomized control plus case‐control study.
Six hundred families (1,200 total cases), including 300 cases with colorectal cancer
(CRC) and or metabolic syndrome to early stages of diabetes, and their family members
in the intervention group, as well as 300 matched control group with cases and family
members, living near the University’s communities will be recruited using stratified
random sampling method with inclusion criteria.