Our research focuses on 1) the physiological and pathological role of neddylation
and deneddylation in the heart, 2) the interplay of the Nedd8 system and protein quality
control, and 3) the role of PQC in the development of diabetic cardiomyopathy. We
will use a combination of novel genetically engineered mouse models with advanced
molecular, cellular and proteomic techniques to tackle these questions.
- The physiological role of SENP8 in the heart.
- Neddylation/deneddylation in cardiac protein quality control.
- Regulation of cardiomyocyte survival by neddylation/deneddylation.
- The ubiquitin proteasome system in diabetic cardiomyopathy.
CURRENT GRANT SUPPORT
American Heart Association Scientist Development Grant (National Center), 11SDG6960011,
Su (PI), 07/01/2011-06/30/2015, The Ubiquitin Proteasome System in Diabetic Cardiomyopathy.
Georgia Health Sciences University Research Initiation Funds
Departmental Start-Up Grant, Su (PI), 08/20/2012-06/30/2015
Neddylation and deneddylation in the heart.
American Heart Association Postdoctoral Fellowship Grant, AHA 0625738Z, Su (PI), 07/01/2006-06/30/2008,
The physiological significance of the COP9 signalosome in adult mouse hearts.
HONORS AND AWARDS
- 2011-2015: American Heart Association Scientist Development Award (National Center).
- 2008: New Investigator Travel Award of the Basic Cardiovascular Sciences Conference
2008 (American Heart Association).
- 2006-2008: American Heart Association Postdoctoral Fellowship.
- 2000: Excellent Graduate Student, Guangxi. University.Respiration/Resuscitation Study
- 1993-1997: Top Scholarship of Guangxi Normal University.
- Neddylation and deneddylation in the heart. 2012 Inaugural Symposium on Ubiquitin,
Protein Quality Control, and Molecular Pathogenesis. Deadwood, SD, USA.
- The COP9 signalosome in the heart. 2011 Inaugural Symposium on Ubiquitin, Protein
Quality Control, and Molecular Pathogenesis. Vermillion, SD, USA.
Jie Li, MD, PhD, Postdoctoral Fellow
Wenxia Ma, MS, Research Assistant