Neal L. Weintraub, M.D.
Professor, Cardiovascular Medicine
|More about Dr. Weintraub|
Dr. Weintraub’s laboratory is focused on vascular biology research with emphasis on oxidative stress, inflammation, and obesity. In particular, his work has advanced the understanding of the role of inflammation and oxidative stress in the pathogenesis of atherosclerosis and aortic aneurysm disease. Through collaborations, the laboratory also participates in research related to remote cardioprotection and stem cell-mediated therapy of the heart. As a clinician, Dr. Weintraub conducts various clinical research projects, including early stage translational research in humans that is derived from the basic science laboratory.
Role of oxidative stress in the pathogenesis of abdominal aortic aneurysms: focused on myeloperoxidase-mediated oxidative stress and therapeutic interruption with niacin. Upstream (GPR109a) and downstream (DP receptor) pathways are also under investigation.
Role of perivascular adipose tissue (PVAT) in the pathogenesis of atherosclerosis: studies are performed using human perivascular adipocytes, and we have developed a novel model of PVAT transplantation into mice.
Role of histone deacetylase-9 in the pathogenesis of obesity-related disease (project headed by Dr. Tapan Chatterjee). This project investigates epigenetic mechanisms of adipose tissue dysfunction in obesity.
Impact of high fat diet on the biology of red blood cells, with an emphasis on the Duffy Antigen Receptor for Chemokines (DARC)- in collaboration with Drs. Julia Brittain and Ryan Harris.
Tapan Chatterjee, PhD.
Rod Pellenberg, M.D.
Nicole Yiew - PhD student (pharmacology) 11/2013-
Rod Pellenberg, MD - postdoctoral fellow 9/2013-
Meaghann Waltman - PhD student (pathobiology, University of Cincinnati), 2009-2013
Journal ArticlesPubMed search for "weintraub nl" [au] +
Weintraub, N.L., Stephenson, A.H., Sprague, R.S., and Lonigro, A.J.: Role of phospholipase A2 in EDHF-mediated relaxation of the porcine coronary artery. In: Endothelium-Dependent Hyperpolarizations, P.M. Vanhoutte (Ed.), Canada, Harwood Academic Publishing, pp. 97-108, 1999.
Chu, Y., Weintraub, N., and Heistad, D.D.: Gene therapy and cardiovascular disease. In: Principles of Molecular Cardiology. M.S. Runge, and C. Patterson, (Eds). Totowa, NJ, Humana Press, pp. 57-69, 2005.
Sanchez CE, Kapur S, Weintraub NL. Aneurysms (large and small arteries). In: Hemostasis and Thrombosis: Basic Principles and Clinical Practice (6th Edition). Pp. 870-882. Wolters Kluwer/Lippincott Williams & Wilkins, Philadelphia, PA, 2012.