S. Sharma Lab

Vascular inflammation plays a critical role in the pathogenesis of diabetic retinopathy. Building on my experience in vascular biology and genomic medicine, my current research focuses on understanding the role of endothelial dysfunction on vascular attributes of diabetic retinopathy. The long-term goal of my lab is to study the role of interleukin-6 (IL-6) signaling in diabetic retinopathy and uncover precise molecular mechanisms to develop novel therapeutic targets. We are currently testing a pharmacological compound, sgp130Fc (fused chimera of extracellular gp130 and the Fc region of IgG1), to selectively inhibit the IL-6 trans-signaling pathway to prevent the inflammation and retinal vascular dysfunction associated with diabetic retinopathy. My lab utilizes both in-vitro and rodent models of diabetic retinopathy to conduct our research.

• Targeting of interleukin-6 classical and trans-signaling in diabetic retinopathy
• Proteomics, glycomics, and glycoproteomic profiling in vision research
• Discerning molecular mechanisms associated with glaucomatous optic neuropathy (glaucoma)

 

 

 

 

 

 

 

 

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Projects

NIH-Funded Projects

1. 'Targeting Interleukin-6 Trans-signaling in Diabetic Retinopathy' (RO1EY026936) [Role: PI].
2. 'Proteomic Biomarkers for Glaucomatous Optic Neuropathy' (RO1EY029728) [Role: Co-I].
3. 'Center Core Grant for Vision Research' (P30EY031631) [Role: Co-director].

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Education

PhD, Biochemistry, University of Lucknow, Lucknow, India

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Teaching

Graduate courses

• Course Director, Translational Genomics and Proteomics (GNMD 8051)
• Course Director, Genomic Medicine Seminar (GNMD 8060)
• Course Director, Functional Genomics and Proteomics Using Animal Models (GNMD 8052) 

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Editorial Board, Frontiers in Oxidant Physiology

I served as the Specialty Chief Editor of Frontiers in Oxidant Physiology (impact factor: 4.566) from 2012 to 2020 and led a team of 215 editors. The journal focuses on interdisciplinary research concerning genetic, biophysical, genomic, proteomic, cellular, molecular, biochemical, physiological, and pharmacological aspects of oxidants and redox active molecules, as well as the pathological events associated with oxidative stress.

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Media Articles

• $3 million National Eye Institute grant supports growth of vision research at MCG, AU
• Augusta University is researching a new drug that might help with diabetes-related blindness
• Powerful anti-inflammatory molecule may block vision loss in diabetic retinopathy
• Augusta University researcher gets $1.5 million grant for eye study
• An anti-inflammatory drug is showing promise in treating diabetic retinopathy
• Our tears could one day tell us if we have glaucoma
• Tag Archives: Shruti Sharma

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Publications

More from PubMed

1. Interleukin-6 trans-signaling mediated regulation of paracellular permeability in human retinal endothelial cells. Glass J, Robinson R, Lee TJ, Sharma A, Sharma S; International Journal of Translational Medicine (2021)
2. Interleukin-6 trans-signaling: a pathway with therapeutic potential for diabetic retinopathy. Sharma S; Frontiers in Physiology (2021)
3. RNA-Seq analysis reveals gene expression changes induced by IL-6 trans-signaling activation in retinal endothelial cells. Robinson R, Brown D, Churchwell L, Lee TJ, Kodeboyina SK, Bloom J, Sharma A, Sharma S; Cytokine (2021)
4. Serum glycoproteomic alterations in patients with diabetic retinopathy. Sharma A, Cox J, Glass J, Lee TJ, Kodeboyina SK, Zhi W, Ulrich L, Lukowski Z, Sharma S; Proteomes (2020)
5. Diabetes induced alterations in murine proteome are mitigated by IL-6 trans-signaling inhibition. Robinson R, Youngblood H, Iyer H, Bloom J, Lee TJ, Chang L, Lukowski Z, Zhi W, Sharma A, Sharma S; Investigative Ophthalmology & Visual Science (2020)
6. Interleukin-6 trans-signaling inhibition prevents oxidative stress in a mouse model of early diabetic retinopathy. Robinson R, Srinivasan M, Shanmugan A, Ward A, Ganapathy V, Bloom J,  Sharma A, Sharma S; Redox Biology (2020) 
7. Proteomic biomarkers of retinal inflammation in diabetic retinopathy. Youngblood H, Robinson R, Sharma A, Sharma S; International Journal Molecular Science (2019)
8. Unraveling the role of genetics in the pathogenesis of diabetic retinopathy. Sharma A, Valle ML, Beveridge C, Liu Y, Sharma S; Eye (2019)
9. Comparative STAT3-regulated gene expression profile in renal cell carcinoma subtypes. Robinson RL, Sharma A, Bai S, Heneidi S, Lee TJ, Kodeboyina SK, Patel N, Sharma S; Frontiers in Oncology (2019)
10. Inhibition of interleukin-6 trans-signaling prevents inflammation and endothelial barrier disruption in retinal endothelial cells. Valle ML, Dworshak J, Sharma A, Ibrahim AS, Al-Shabrawey M, Sharma S; Experimental Eye Research (2019)
11. Proteomic alterations in aqueous humor from patients with primary open angle glaucoma. Sharma S, Bollinger KE, Kodeboyina SK, Zhi W, Patton J, Bai S, Edwards B, Ulrich L, Bogorad D, Sharma A; Investigative Ophthalmology & Visual Science (2018)
12. IGF-binding proteins in type-1 diabetes are more severely altered in the presence of complications. Sharma A, Purohit S, Sharma S, Bai S, Zhi W, Ponny SR, Hopkins D, Steed L, Bode B, Anderson SW, She JX; Frontiers in Endocrinology (2016)
13. Elevated serum levels of soluble TNF receptors and adhesion molecules are associated with diabetic retinopathy in patients with type-1 diabetes. Sharma S, Purohit S, Sharma A, Hopkins D, Steed L, Bode B, Anderson SW, Caldwell R, She JX; Mediators of Inflammation (2015)
14. Endothelin-1 induces a glycolytic switch in pulmonary arterial endothelial cells via the mitochondrial translocation of endothelial nitric oxide synthase. Sun X, Kumar S, Sharma S, Aggarwal S, Lu Q, Gross C, Rafikova O, Lee SG, Dasarathy S, Hou Y, Meadows ML, Han W, Su Y, Fineman JR, Black SM; American Journal of Respiratory Cell and Molecular Biology (2014)
15. Dimethylarginine dimethylaminohydrolase II overexpression attenuates LPS-mediated lung leak in acute lung injury. Aggarwal S, Gross CM, Kumar S, Dimitropoulou C, Sharma S, Gorshkov BA, Sridhar S, Lu Q, Bogatcheva NV, Jezierska-Drutel AJ, Lucas R, Verin AD, Catravas JD, Black SM; American Journal of Respiratory Cell and Molecular Biology (2014)
16. Rosiglitazone preserves pulmonary vascular function in lambs with increased pulmonary blood flow. Oishi PE, Sharma S, Datar SA, Kumar S, Aggarwal S, Lu Q, Raff G, Azakie A, Hsu JH, Sajti E, Fratz S, Black SM, Fineman JR; Pediatric Research (2013)
17. L-carnitine preserves endothelial function in a lamb model of increased pulmonary blood flow. Sharma S, Aramburo A, Rafikov R, Sun X, Kumar S, Oishi PE, Datar SA, Raff G, Xoinis K, Kalkan G, Fratz S, Fineman JR, Black SM; Pediatric Research (2013)
18. Disruption of endothelial cell mitochondrial bioenergetics in lambs with increased pulmonary blood flow. Sun X, Sharma S, Fratz S, Kumar S, Rafikov R, Aggarwal S, Rafikova O, Lu Q, Burns T, Dasarathy S, Wright J, Schreiber C, Radman M, Fineman JR, Black SM; Antioxidants & Redox Signaling (2013)
19. Chronic inhibition of PPAR-γ signaling induces endothelial dysfunction in the juvenile lamb. Sharma S, Barton J, Rafikov R, Aggarwal S, Kuo HC, Oishi PE, Datar SA, Fineman JR, Black SM; Pulmonary Pharmacology & Therapeutics (2013)
20. Role of carnitine acetyl transferase in regulation of nitric oxide signaling in pulmonary arterial endothelial cells. Sharma S, Sun X, Agarwal S, Rafikov R, Dasarathy S, Kumar S, Black SM; International Journal of Molecular Sciences (2012)
21. Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I. Sharma S, Sun X, Kumar S, Rafikov R, Aramburo A, Kalkan G, Tian J, Rehmani I, Kallarackal S, Fineman JR, Black SM; Free Radical Biology & Medicine (2012)
22. Glutathione supplementation attenuates lipopolysaccharide-induced mitochondrial dysfunction and apoptosis in a mouse model of acute lung injury. Aggarwal S, Dimitropoulou C, Lu Q, Black SM, Sharma S; Frontiers in Physiology (2012)
23. PPAR-γ regulates carnitine homeostasis and mitochondrial function in a lamb model of increased pulmonary blood flow. Sharma S, Sun X, Rafikov R, Kumar S, Hou Y, Oishi PE, Datar SA, Raff G, Fineman JR, Black SM; PLOS One (2012) 

 

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