Research in the Vision Research Laboratory focuses on identifying therapeutic targets for vision-related disorders such as diabetic
retinopathy and optic neuritis. The lab employs both in vivo and in vitro approaches to investigate the role of arginase/polyamine pathway in retinal neuro-vascular injury. We have previously shown that arginase, the urea cycle enzyme regulate neuro-glial injury and retinal function in models of retinal neurodegeneration. Current projects explore the cellular and molecular mechanisms by which neuronal arginase and and its downstream signaling partner, polyamine oxidase, are involved in neuro-vascular protection during retinal injuries. Experiments using knockout mice, cultured cells, and pharmacological inhibitors in ocular disease models have significant implications in development of new therapies for vision problems.
• Role of neuronal arginase on vascular protection during ischemic retinopathy. Principal Investigator
Scientist Development Grant (American Heart Association):7/1/2011- 6/30/2015
• Cellular mechanisms of retinopathy: Role of arginase. Co-Investigator
NIH/NEI RO1: 4/1/2013 – 3/31/2018
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